Systemic sensitivity to corticosteroids in smokers with asthma
نویسندگان
چکیده
منابع مشابه
Systemic sensitivity to corticosteroids in smokers with asthma.
Cigarette smokers with asthma are insensitive to the therapeutic effects of corticosteroids. It is not known whether this insensitivity to corticosteroids in smokers affects tissue sites beyond the airways. A total of 75 asthmatic subjects (39 smokers) and 78 healthy controls (30 smokers) were recruited to an observational study. The cutaneous and peripheral blood lymphocyte responses to cortic...
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Asthma is a complex disease of the respiratory tract associated with chronic inflammation in which an intricate network of cells and cellular factors plays a major role. Asthma is one of the most common chronic diseases, with an estimated 300 million cases worldwide, imposing a considerable burden on society in morbidity, quality of life, and healthcare costs. Inhaled corticosteroids (ICSs) for...
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BACKGROUND The airway edema and secretions associated with acute asthma are most effectively treated with anti-inflammatories such as corticosteroids delivered by inhaled, oral, intravenous or intra-muscular routes. There is an unresolved debate about the use of systemic corticorticoids in the early treatment of acute asthma for emergency department patients. OBJECTIVES To determine the benef...
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Introduction: Asthma exacerbation is common in children. Treatment with oral corticosteroids (OCS) and inhaled corticosteroids are suggested for asthma exacerbation. It is shown that inhaled corticosteroids has similar outcome in reducing asthma symptoms compared to OCS. But few studies have evaluated the pulmonary function changes in these two treatments. In this study, we evaluated the chang...
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Nitric oxide (NO), a gaseous signaling molecule generated by NO synthase (NOS), is enhanced by inflammatory stimuli [1]. The exhaled nitric oxide fraction (FeNO) has been proposed as a marker of airway inflammation and a guide for anti-inflammatory therapy in asthma [1]. However, a persistently high FeNO is occasionally observed despite inhaled corticosteroids (ICS) therapy [2-4]. Excessive NO ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2006
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.06.00120505